NESOSPRAY HE: Rapid and Effective Relief from Rhinosinusitis, Rhinitis, and Nasal Congestion


NESOSPRAY HE from Vitrobio is an innovative nasal spray designed for the treatment of rhinosinusitis, rhinitis, and nasal congestion. It works by creating a filmogenic liquid bandage on the nasal mucosal surface, providing hydration, cleansing, and reducing contaminants and pro-inflammatory proteins through osmotic action. Clinical trials have shown a 34% reduction in nasal congestion within 30 minutes and a 48% reduction within 3 days. Other significant improvements were observed in headache and facial pain, with a 64% and 62% reduction respectively within 3 days. The quality of life of the patients also improved significantly.

Introducing NESOSPRAY HE


Vitrobio presents NESOSPRAY HE, a novel solution specifically designed for the treatment of rhinosinusitis, rhinitis, and nasal congestion. This product is a nasal spray in a convenient 15 ml format, designed for easy application and optimal delivery of the active components.


Targeted Proteins and Actions


  1. Protective Barrier Effect: NESOSPRAY HE works by creating a filmogenic liquid bandage on the nasal mucosal surface. This protective barrier shields the nasal mucosa from further irritation or infection, providing an immediate layer of defense.

  2. Osmotic Action: The spray also exerts an osmotic action, which attracts fluids towards the exterior, helping to massively unblock congested sinuses. This osmotic action also cleanses the nasal mucosa by effectively drawing out contaminants, debris, and pro-inflammatory proteins such as cytokines and interleukins. This dual action of unblocking and cleansing provides immediate relief and creates a clean environment conducive to healing.

  3. Cellular Repair and Growth Effect: With the nasal mucosa now in a clean and protected state, the healing process can effectively begin. The spray promotes cell growth and repair, allowing the nasal mucosa to regenerate and regain its integrity. This restoration of the nasal mucosa is crucial for long-term relief from rhinosinusitis, rhinitis, and nasal congestion.



Clinical Trials and Results

The effectiveness of NESOSPRAY HE has been evaluated in a randomized, double-blind clinical trial against a placebo, conducted over 3 weeks with 56 patients. The trial included patients with rhinosinusitis, encompassing all symptoms related to this condition.

The main results of the trial were highly promising. There was a 34% reduction in nasal congestion within 30 minutes.

Interestingly, the product initially increased nasal secretions (rhinorrhea) by 25% within 30 minutes of application due to its strong osmotic action. However, a 50% reduction in rhinorrhea was observed within a week, attributed to the healing and repair of the nasal mucosa.



In conclusion, NESOSPRAY HE represents a significant advancement in the treatment of rhinosinusitis, rhinitis, and nasal congestion. Its unique mechanism of action, combined with its ease of use and rapid results, make it a promising addition to the therapeutic options available for these common conditions.



Understanding Rhinosinusitis, Rhinitis, and Nasal Congestion

Rhinosinusitis, rhinitis, and nasal congestion are common health issues that can significantly affect individuals’ comfort and quality of life. These conditions are characterized by inflammation and swelling in the nose and sinuses, leading to symptoms such as a runny or stuffy nose, sneezing, and facial pain or pressure.


Causes and Symptoms of Rhinosinusitis, Rhinitis, and Nasal Congestion

These conditions can be caused by various factors, including viral infections (like the common cold or flu), allergies, and environmental irritants. In individuals of all ages, these conditions can also be exacerbated by factors such as exposure to secondhand smoke, changes in weather, or underlying health conditions like asthma.

The symptoms of rhinosinusitis, rhinitis, and nasal congestion can be particularly bothersome, affecting sleep, productivity, and overall quality of life. These symptoms can also lead to other complications, such as sinusitis or ear infections, if not properly treated.


Treatment for Rhinosinusitis, Rhinitis, and Nasal Congestion

Treatment for these conditions typically involves managing the symptoms and addressing the underlying cause. This can include the use of over-the-counter remedies, prescription medications, and in some cases, lifestyle changes or procedures. It’s important for individuals to consult with a healthcare provider to determine the best course of treatment for their condition.


Prevention of Rhinosinusitis, Rhinitis, and Nasal Congestion

Prevention strategies include regular hand washing, avoiding known allergens, and maintaining a healthy indoor environment. Regular check-ups with a healthcare provider can also help detect and manage these conditions early.



Rhinosinusitis, rhinitis, and nasal congestion can significantly impact an individual’s wellbeing. Understanding these conditions, their causes, symptoms, and treatment options can help individuals seek timely medical care and manage their symptoms effectively. With the right treatment, such as NESOSPRAY HE, individuals can find relief from these common conditions and enjoy a better quality of life.


  • Mechanical mode of action 
  • Instant osmotic action 
  • Clears, decongests and cleanses the sinuses
  • Dual action: Relieves and protects
  • Reduces contaminants on the nasal surface
  • Reduces nasal congestion, sinus pain (<30min)
  • Reduce all the rhinosinusitis symptoms
  • Reduces the need for antibiotics
  • No drowsiness . No habituation effect
  • Fast action

Randomized, double-blind clinical trial

General informations

Title : Clinical Efficacy of a New Filmogen Polymeric Glycerol Solution for the Treatment of Rhinosinusitis

Journal : Journal of Clinical Respiratory Diseases and Care (2017)

Patients: N=56 | Test product = 39 ; Comparator = 17

Duration : 2 weeks

Inclusion : Patients with rhinosinusitis including all symptoms

Link: 6-Rhinosinusitis-Clin-J-Clin-Resp-Dis-Care-2017


Main results


  • 34 % reduction in nasal congestion within 30 min
  • 48 % reduction in nasal congestion within 3 days


  • 25% augmentation in rhinorrhea within 30 min (because the product strongly increases nasal secretions after application)
  • 50% reduction in rhinorrhea with a week (due to the healing and repair of the mucosa)


  • 64% reduction in headache within 3 days
  • 62% reduction in facial pain within 3 days
  • Improvement of the quality of life
IndicationFilmogen liquid bandage for the treatment of rhinosinusitis, rhinitis and nasal congestion.
CompositionFilmogenic glycerol, HPC, water, EO : Mentha, Eucalypt, Thym and Rosmar.
PresentationNasal spray 15ml
ClassMDD Class I | MDR Class IIa
DirectionApply 2 sprays in each nostril, 2-3 times a day
PrecautionsFor topical use only (nasal cavity). Keep out of reach and sight of children.
Age 18+
Storage conditionsBelow 25°C
Legal manufacturer VITROBIO (France)
Product code NHE