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Throat infection – Pharyndol

Throat infection Kids

 

Physiopathology:

Influenza virus can attach to the throat cell surface through Glycoproteins (GPs) such as Hemagglutinin & Neuraminidase (H1N1, H6N9), but cannot enter into the cells without the help of some topically available proteolytic enzymes (proteases) which break the cell membrane. Once inside the cells, the virus multiplies, and millions of new virus particles are liberated on the throat surface. They attack new cells, weaken local defenses, facilitate secondary bacterial growth, and generate clinical signs of the flu. Liberation of inflammatory cytokines produces inflammation & pain. In the absence any topical anti-virals, only symptomatic treatments are currently used.

Ideal Treatment should:

Act instantly, topically, be non-irritant; stop virus growth; remove contaminants; keep the throat surface hydrated; minimize the need for antibiotics.

Currently available treatments:

Topical anti-virals: None; Preventive drugs: None; Symptomatic: >100 (9/10 OTCs in pharmacies). Antibiotics have no effect on viruses.

20mL kid Spray For the treatment of Throat Infections

 

 

 

Viral throat infection in children:

Virus surface glycoproteins (such as H1N1) and inflammatory cytokines are protein molecules. As multiple proteins are involved in a single infection, they cannot be blocked with a single chemical or biological molecule. This is the reason why all current treatments are mono-target & have poor efficacy.

The aim of VITROBIO’s research was to find a multi-target, fast-acting, throat-cleaning, topical & safe treatment which is adapted for children.

In 1994, Vitrobio discovered & patented a hypertonic viscous liquid solution, based on Glycerol: VB-Gy, 18 times more osmotically active than sea water yet NON-IRRITANT, capable of generating an instant flow of hypotonic liquid when applied on a live biological, semi-permeable, membrane (International patent 1997: PCT/FR99/01340). Applying this solution on the throat surface, creates a strong outward flow of hypotonic liquid, detaching & draining all the free-floating virus particles as well as other contaminants present on the throat surface.

Cleaning the throat mucosa of all the contaminants including bacteria & viruses, creates a favorable environment for cell growth & throat mucosa repair.

The osmotically active, stable, flexible, and throat cleaning topical filmogen solution is patented by Vitrobio (N° PCT/EP2013/061835).

This mode of action of Pharyndol is nearly instant, without the use of chemical and toxic ingredients, totally safe and well adapted for children.

If used during the early phase of the disease, Pharyndol Kid spray attenuates the severity & duration of throat infection.

 

Product presentation: 20mL spray

Posology: 4-5 sprays 3-4 times a day up to complete recovery.

Regulatory Status: Due to the mechanical topical filmogen activity without any pharmacological, biological, metabolic or immunological interaction with the cellular structure:  Class I Medical Device in Europe.

Contraindications: Not to be used in pediatric population under 3 years of age. Side Effects: This product has no known side effects.

 

Clinical Efficacy:

A comparative, randomized, double-blind, parallel group  clinical trial study was conducted at Malons Multispeciality Hospital and ICU (Navi Mumbai/India) to evaluate the efficacy and safety of Vitrobio’s throat spray for kids versus 0.9% NaCl saline solution spray in the treatment of throat infections in children. Dates of the study: 18/09/2018-27/10/2018 (5 weeks). 30 patients aged 3-15 years old. Study number: VB-PHR/OBS/2018. The results of the study show that the test product strongly suppresses throat infection symptoms (difficulty swallowing, swollen throat, throat irritation, throat redness, whitish deposit on throat). No adverse side effects were reported.

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